Nature Communications (Mar 2022)

Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium

  • Tsunaki Higa,
  • Yasutaka Okita,
  • Akinobu Matsumoto,
  • Shogo Nakayama,
  • Takeru Oka,
  • Osamu Sugahara,
  • Daisuke Koga,
  • Shoichiro Takeishi,
  • Hirokazu Nakatsumi,
  • Naoki Hosen,
  • Sylvie Robine,
  • Makoto M. Taketo,
  • Toshiro Sato,
  • Keiichi I. Nakayama

DOI
https://doi.org/10.1038/s41467-022-29165-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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Rapid turnover and regeneration of intestinal epithelium requires distinct intestinal stem cell (ISC) populations. Here the authors show p57 marks quiescent ISCs, and that differentiated cells revert to stem cell state after injury, through dynamic reprogramming characterized by fetal- and metaplastic-like changes.