Nature Communications (Jul 2017)
BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease
- Joaquim Miguel Vieira,
- Sara Howard,
- Cristina Villa del Campo,
- Sveva Bollini,
- Karina N. Dubé,
- Megan Masters,
- Damien N. Barnette,
- Mala Rohling,
- Xin Sun,
- Laura E. Hankins,
- Daria Gavriouchkina,
- Ruth Williams,
- Daniel Metzger,
- Pierre Chambon,
- Tatjana Sauka-Spengler,
- Benjamin Davies,
- Paul R. Riley
Affiliations
- Joaquim Miguel Vieira
- Department of Physiology, Burdon Sanderson Cardiac Science Centre, Anatomy and Genetics, University of Oxford
- Sara Howard
- Molecular Medicine Unit, UCL Institute of Child Health
- Cristina Villa del Campo
- Department of Physiology, Burdon Sanderson Cardiac Science Centre, Anatomy and Genetics, University of Oxford
- Sveva Bollini
- Department of Physiology, Burdon Sanderson Cardiac Science Centre, Anatomy and Genetics, University of Oxford
- Karina N. Dubé
- Molecular Medicine Unit, UCL Institute of Child Health
- Megan Masters
- Department of Physiology, Burdon Sanderson Cardiac Science Centre, Anatomy and Genetics, University of Oxford
- Damien N. Barnette
- Department of Physiology, Burdon Sanderson Cardiac Science Centre, Anatomy and Genetics, University of Oxford
- Mala Rohling
- Department of Physiology, Burdon Sanderson Cardiac Science Centre, Anatomy and Genetics, University of Oxford
- Xin Sun
- Department of Physiology, Burdon Sanderson Cardiac Science Centre, Anatomy and Genetics, University of Oxford
- Laura E. Hankins
- Department of Physiology, Burdon Sanderson Cardiac Science Centre, Anatomy and Genetics, University of Oxford
- Daria Gavriouchkina
- Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Ruth Williams
- Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Daniel Metzger
- Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U964/CNRS UMR 7104/Université de Strasbourg
- Pierre Chambon
- Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U964/CNRS UMR 7104/Université de Strasbourg
- Tatjana Sauka-Spengler
- Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Benjamin Davies
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Paul R. Riley
- Department of Physiology, Burdon Sanderson Cardiac Science Centre, Anatomy and Genetics, University of Oxford
- DOI
- https://doi.org/10.1038/ncomms16034
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Priming of the adult mouse heart with Tβ4 activates dormant epicardium-derived cells to aid repair of injured myocardium. Here, Vieiraet al. explain this process and show that Tβ4 binds a chromatin remodeller BRG1 and activates Wt1, the key regulator of epicardial epithelial-to-mesenchymal transformation, by altering the epigenetic landscape of the Wt1 locus.
