Data highlighting the expression of two miR-132/212 target genes—Sirt1 and Pten—after chronic stress
Sydney Aten,
Chloe E. Page,
Anisha Kalidindi,
Kelin L. Wheaton,
Anzela Niraula,
Jon P. Godbout,
Kari R. Hoyt,
Karl Obrietan
Affiliations
Sydney Aten
Department of Neuroscience, Ohio State University, Columbus, OH, USA
Chloe E. Page
Department of Neuroscience, Ohio State University, Columbus, OH, USA
Anisha Kalidindi
Department of Neuroscience, Ohio State University, Columbus, OH, USA
Kelin L. Wheaton
Division of Pharmaceutics and Pharmaceutical Chemistry, Ohio State University, Columbus, OH, USA
Anzela Niraula
Department of Neuroscience, Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA
Jon P. Godbout
Department of Neuroscience, Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA; Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, OH, USA
Kari R. Hoyt
Division of Pharmaceutics and Pharmaceutical Chemistry, Ohio State University, Columbus, OH, USA
Karl Obrietan
Department of Neuroscience, Ohio State University, Columbus, OH, USA; Corresponding author.
The data presented here are related to our research article entitled “miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior” (Aten et al., 2018). In this article, we utilize immunofluorescent techniques to examine the protein-level expression of two microRNA-132/212 target genes, Sirt1 and Pten, in miR-132 transgenic and miR-132/212 conditional knockout (cKO) mouse lines. Additionally, using immunohistochemistry, we detail the expression profile of Sirt1 and Pten in the hippocampus and amygdala of WT mice after a 15 day chronic restraint stress paradigm.
