Nature Communications (Sep 2017)
Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes
- Satoshi Kojo,
- Hirokazu Tanaka,
- Takaho A. Endo,
- Sawako Muroi,
- Ye Liu,
- Wooseok Seo,
- Mari Tenno,
- Kiyokazu Kakugawa,
- Yoshinori Naoe,
- Krutula Nair,
- Kazuyo Moro,
- Yoshinori Katsuragi,
- Akinori Kanai,
- Toshiya Inaba,
- Takeshi Egawa,
- Byrappa Venkatesh,
- Aki Minoda,
- Ryo Kominami,
- Ichiro Taniuchi
Affiliations
- Satoshi Kojo
- Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS)
- Hirokazu Tanaka
- Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS)
- Takaho A. Endo
- Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences (IMS)
- Sawako Muroi
- Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS)
- Ye Liu
- Division of Genomic Technologies, RIKEN Center for Life Science Technologies (CLST)
- Wooseok Seo
- Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS)
- Mari Tenno
- Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS)
- Kiyokazu Kakugawa
- Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS)
- Yoshinori Naoe
- Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS)
- Krutula Nair
- Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS)
- Kazuyo Moro
- Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences (IMS)
- Yoshinori Katsuragi
- Division of Molecular Biology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University
- Akinori Kanai
- Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University
- Toshiya Inaba
- Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University
- Takeshi Egawa
- Department of Pathology and Immunology, School of Medicine, Washington University School of Medicine
- Byrappa Venkatesh
- Institute of Molecular and Cell Biology, Agency for Science, Technology and Research
- Aki Minoda
- Division of Genomic Technologies, RIKEN Center for Life Science Technologies (CLST)
- Ryo Kominami
- Division of Molecular Biology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University
- Ichiro Taniuchi
- Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS)
- DOI
- https://doi.org/10.1038/s41467-017-00768-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper expression of ThPOK and Runx3 and correct CD4/CD8 lineage commitment.
