Spatial Synchronization of Hemodynamics and Metabolism in Norm

Abstract

Synchronization of the curves of central and peripheral hemodynamics, according to the data obtained during catheterization, showed the intersection points of the graphical pressure curves, which were shown in previous works. The three-chamber block of the ventricles (with leading role of LV) in the isometric contraction phase (D(Q)) generates three wave impulses: 1) retrograde impulse of CS directed to the zone of the integral combination (hemodynamics, metabolites of metabolic zones, hormones) and partial interference of venous flows coming to RA (end section of SC); 2) anterograde impulse of RV, which heads to the exchange zone of the lung (initial section of PC) and outrunning of the “venous bolus”; 3) anterograde impulse of LV, ahead of the “arterial bolus” (initial section of SC), leaving along Ao into the vascular bed to the exchange zones of peripheral organs. We have interpreted intersections of hemodynamic curves as “zone of temporal equalization of pressure” (ZTEP), both in the heart and in remote topographic zones. Based on the results of previous works, we built separate ZTEP plots for the high- and low-energy phases of the cardiac cycle (CC), relative to CMIP. The genesis and development of key points of the low-energy phase are considered. We believe that the distributed ZTEP matrix created in the vascular bed during each CC, consisting of short-term synchronous equal-sized pressor structures interfering with the Ao wave impulse, has a regulatory effect on the CC phase sequence, the hemodynamics of organs (including peripheral resistance), and metabolism. The systemic distributed ZTEP association—a formed CMIP—is a synchronized (between ZTEPs, with the phases of CC, and ECG), high-speed, information-regulatory structure of the interaction of hemodynamics and metabolism of both central and peripheral organs, which is involved in the control and regulation of homeostasis as a whole.

Keywords

• cardiosynchronization
• pulse wave
• cardiac hemodynamics
• hemostasis