Nature Communications (Aug 2021)
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
- Rokana Taftaf,
- Xia Liu,
- Salendra Singh,
- Yuzhi Jia,
- Nurmaa K. Dashzeveg,
- Andrew D. Hoffmann,
- Lamiaa El-Shennawy,
- Erika K. Ramos,
- Valery Adorno-Cruz,
- Emma J. Schuster,
- David Scholten,
- Dhwani Patel,
- Youbin Zhang,
- Andrew A. Davis,
- Carolina Reduzzi,
- Yue Cao,
- Paolo D’Amico,
- Yang Shen,
- Massimo Cristofanilli,
- William A. Muller,
- Vinay Varadan,
- Huiping Liu
Affiliations
- Rokana Taftaf
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Xia Liu
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Salendra Singh
- Case Comprehensive Cancer Center, Case Western Reserve University
- Yuzhi Jia
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Nurmaa K. Dashzeveg
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Andrew D. Hoffmann
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Lamiaa El-Shennawy
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Erika K. Ramos
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Valery Adorno-Cruz
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Emma J. Schuster
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- David Scholten
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Dhwani Patel
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Youbin Zhang
- Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine
- Andrew A. Davis
- Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine
- Carolina Reduzzi
- Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine
- Yue Cao
- Department of Electrical and Computer Engineering, TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University
- Paolo D’Amico
- Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine
- Yang Shen
- Department of Electrical and Computer Engineering, TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University
- Massimo Cristofanilli
- Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine
- William A. Muller
- Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Vinay Varadan
- Case Comprehensive Cancer Center, Case Western Reserve University
- Huiping Liu
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25189-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Circulating tumor cell (CTC) clusters are more efficient at mediating metastasis as compared to single cells and are associated with poor prognosis in breast cancer. Here, the authors show that ICAM1 is enriched in CTC clusters and its loss suppresses cell-cell interaction and CTC cluster formation, and propose ICAM1 as a therapeutic target for treating breast cancer metastasis.
