Research progress of NLRP3 inflammasome in the pathogenesis of psoriasis

Abstract

NLRP3 inflammasome activates IL-1β and IL-18. In recent years, a large number of in vitro and in vivo studies showed elevations in expression levels of NLRP3 inflammasome, IL-1β and IL-18 in psoriasis. The involvement of NLRP3 inflammasome in the pathogenesis of psoriasis may be related to the activation of NF-κB, P2X7, S1PR1 and miRNA155. Blocking NLRP3 inflammasome may affect AMPK and SIRT1 molecules as well as T cell signaling pathways in psoriasis models. Here we review the association of NLRP3 and psoriasis, the possible mechanisms by which NLRP3 regulates the progress of psoriasis and the changes in inflammatory pathway after blockade of NLRP3.

Keywords

• psoriasis
• nlrp3 inflammasome
• il-1β
• il-18