Characterization of the synthetic biology-inspired implementation of a materials-based positive feedback loop
Hanna J. Wagner,
Raphael Engesser,
Kathrin Ermes,
Christian Geraths,
Jens Timmer,
Wilfried Weber
Affiliations
Hanna J. Wagner
Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Albertstrasse 19a, 79100 Freiburg, Germany; BIOSS - Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany
Raphael Engesser
BIOSS - Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany; Institute of Physics, University of Freiburg, Hermann-Herder Strasse 3, 79104 Freiburg, Germany
Kathrin Ermes
Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany; BIOSS - Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany
Christian Geraths
Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany; BIOSS - Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany
Jens Timmer
BIOSS - Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany; Institute of Physics, University of Freiburg, Hermann-Herder Strasse 3, 79104 Freiburg, Germany
Wilfried Weber
Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Albertstrasse 19a, 79100 Freiburg, Germany; BIOSS - Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany; Corresponding author at: Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany.
The translation of engineering designs to materials sciences by means of synthetic biological tools represents a novel concept for the development of information-processing materials systems. Here, we provide data on the mathematical model-guided implementation of a biomaterials-based positive feedback loop for the detection of proteolytic activities. Furthermore, we present data on an extended system design for the detection of the antibiotic novobiocin.This work is related to the research article “Synthetic biology-inspired design of signal-amplifying materials systems” (Wagner et al., 2018) [1]. Keywords: Information-processing, Protease, Signal amplification, Smart materials, Stimulus-responsive
