Pancreatic islets implanted in an irreversible electroporation generated extracellular matrix in the liver

Abstract

Pancreatic islet transplantation via infusion through the portal vein, has become an established clinical treatment for patients with type 1 diabetes. Because the engraftment efficiency is low, new approaches for pancreatic islets implantation are sought. The goal of this study is to explore the possibility that a non-thermal irreversible electroporation (NTIRE) decellularized matrix in the liver could be used as an engraftment site for pancreatic islets.

Keywords

• liver cancer
• pancreatic islet transplantation
• non-thermal irreversible electroporation
• tissue engineering
• diabetes