Neuropsychiatric Disease and Treatment (Mar 2022)
Amplitude of Low-Frequency Oscillations in First-Episode Drug-Naive Patients with Major Depressive Disorder: A Resting State Functional Magnetic Resonance Imaging Study
Abstract
Lulu Zhang,1 Xinghua Wei,2 Jingping Zhao3 1Department of Psychiatry, Guangzhou First People’s Hospital, Guangzhou, Guangdong, People’s Republic of China; 2Department of Medical Imaging, Guangzhou First People’s Hospital, Guangzhou, Guangdong, People’s Republic of China; 3Department of Psychiatry and Mental Health Institute of the Second Xiangya Hospital, Central South University, Chinese National Clinical Research Center on Mental Disorders, Chinese National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Lulu Zhang, Department of Psychiatry, Guangzhou First People’s Hospital, 1 Panfu Road, Guangzhou, Guangdong, People’s Republic of China, Tel/Fax +86 2081046473, Email [email protected]: To observe characteristics of the amplitudes of low-frequency oscillation (LFO) in first-episode drug-naive patients with major depressive disorder (MDD).Methods: Amplitudes of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were computed using resting-state functional magnetic resonance imaging (rs-fMRI) data of 39 first-episode drug-naive patients with MDD and 37 healthy controls.Results: ALFF and fALFF in the left cerebellum were significantly higher in patients with MDD compared to control group, while ALFF in the right rolandic operculum was significantly lower (all p < 0.001, AlphaSim correction).Conclusion: Abnormal neurological activity in multiple brain regions in first-episode drug-naive patients with MDD may be involved in the neurobiological mechanisms of MDD and should be considered in future studies.Keywords: major depressive disorder, first-episode, ALFF, fALFF, fMRI
