Nature Communications (Aug 2017)
Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
Abstract
Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.