Nature Communications (Aug 2017)

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

  • Sanae Ben Mkaddem,
  • Amaya Murua,
  • Héloise Flament,
  • Dimitri Titeca-Beauport,
  • Carine Bounaix,
  • Luca Danelli,
  • Pierre Launay,
  • Marc Benhamou,
  • Ulrich Blank,
  • Eric Daugas,
  • Nicolas Charles,
  • Renato C. Monteiro

DOI
https://doi.org/10.1038/s41467-017-00294-0
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.