Lipid remodeling during early development of rainbow trout (Oncorhynchus mykiss)

Chao Wang; Yufeng Gong; Fuchang Deng; Xin Liu; Enming Ding; Shuyi Zhang; Xiao Ma; Jason Raine; Paul D. Jones; Song Tang; John P. Giesy

Aquaculture Reports (Apr 2024)

Lipid remodeling during early development of rainbow trout (Oncorhynchus mykiss)

Chao Wang,
Yufeng Gong,
Fuchang Deng,
Xin Liu,
Enming Ding,
Shuyi Zhang,
Xiao Ma,
Jason Raine,
Paul D. Jones,
Song Tang,
John P. Giesy

Affiliations

Chao Wang: China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada
Yufeng Gong: College of Marine Life Sciences, Ocean University of China, Yushan Road 5, Qingdao, Shandong, China; Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada; Correspondence to: College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong, China.
Fuchang Deng: China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China
Xin Liu: Department of Occupational Disease Prevention and Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China
Enming Ding: China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China
Shuyi Zhang: China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China
Xiao Ma: China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China
Jason Raine: Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada
Paul D. Jones: Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada
Song Tang: China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China; Corresponding author at: China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
John P. Giesy: Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada; Department of Integrative Biology and Center for Integrative Toxicology, Michigan State University, 1129 Farm Lane Road, East Lansing, MI, USA; Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK, Canada

Journal volume & issue: Vol. 35
p. 102005

Abstract

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Lipids play a crucial role in a range of physiological processes, with a particular significance during the early development stages. However, our understanding of lipid remodeling in cold-water salmon species during these critical early developmental phases remains limited. To address this, a comprehensive lipidomic study was conducted using rainbow trout (Oncorhynchus mykiss) as a model and four critical developmental stages were selected for analysis (i.e., newly fertilized eggs, eyed stage, post-hatch sac-fry stage, and swim-up stage). As expected, our results demonstrated significant lipid alterations during early development of rainbow trout. Through fuzzy c-mean clustering analysis, our study further provided a detailed description on the dynamic changes and regulation of the lipidome. Most unsaturated phosphatidylcholines (PCs) excluding very long-chain polyunsaturated PCs and all polyunsaturated triacylglycerols (TGs) were continuously consumed, suggesting that they are the major energy sources and/or precursor substances for early-stage development in rainbow trout. Gradual increases in very long-chain polyunsaturated phosphatidylethanolamines (PEs) and PCs, phosphatidylserines (PSs), as well as saturated and monounsaturated sphingomyelins (SMs) were observed in this study, which may closely associate with retina and brain development, and the myelination process. Additionally, diacylglycerol (DG), a well-known second messenger, displayed continuous synthesis throughout embryogenesis in this study. In addition to the abovementioned lipid dynamics, our study also found distinct patterns of change in certain glycerophospholipids (GP) isomers, while all glycerolipid (GL) isomers exhibited consistent trends in alteration, indicating different GP isomers may have different biological functions or activities for early development. Overall, this study emphasized the significant roles of lipids during the early development of rainbow trout and served as an informational data set for fish development-related research.

Published in Aquaculture Reports

ISSN: 2352-5134 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Agriculture: Aquaculture. Fisheries. Angling
Website: http://www.journals.elsevier.com/aquaculture-reports/

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