Nature Communications (Nov 2020)
Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2
- Jon Arizti-Sanz,
- Catherine A. Freije,
- Alexandra C. Stanton,
- Brittany A. Petros,
- Chloe K. Boehm,
- Sameed Siddiqui,
- Bennett M. Shaw,
- Gordon Adams,
- Tinna-Solveig F. Kosoko-Thoroddsen,
- Molly E. Kemball,
- Jessica N. Uwanibe,
- Fehintola V. Ajogbasile,
- Philomena E. Eromon,
- Robin Gross,
- Loni Wronka,
- Katie Caviness,
- Lisa E. Hensley,
- Nicholas H. Bergman,
- Bronwyn L. MacInnis,
- Christian T. Happi,
- Jacob E. Lemieux,
- Pardis C. Sabeti,
- Cameron Myhrvold
Affiliations
- Jon Arizti-Sanz
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Catherine A. Freije
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Alexandra C. Stanton
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Brittany A. Petros
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Chloe K. Boehm
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Sameed Siddiqui
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Bennett M. Shaw
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Gordon Adams
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Tinna-Solveig F. Kosoko-Thoroddsen
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Molly E. Kemball
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Jessica N. Uwanibe
- African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer’s University
- Fehintola V. Ajogbasile
- African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer’s University
- Philomena E. Eromon
- African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer’s University
- Robin Gross
- Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Loni Wronka
- National Biodefense Analysis and Countermeasures Center
- Katie Caviness
- National Biodefense Analysis and Countermeasures Center
- Lisa E. Hensley
- Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Nicholas H. Bergman
- National Biodefense Analysis and Countermeasures Center
- Bronwyn L. MacInnis
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Christian T. Happi
- African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer’s University
- Jacob E. Lemieux
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Pardis C. Sabeti
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- Cameron Myhrvold
- Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
- DOI
- https://doi.org/10.1038/s41467-020-19097-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
The COVID-19 pandemic has highlighted the need for user-friendly diagnostic techniques. Here, the authors present SHINE, a streamlined and optimised Cas13-based method with accompanying smartphone app for visual diagnosis.
