Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

Mai Tram Vo; Barbara J. Smith; John Nicholas; Young Bong Choi

doi:10.1038/s41467-019-11164-2

Nature Communications (Jul 2019)

Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

Mai Tram Vo,
Barbara J. Smith,
John Nicholas,
Young Bong Choi

Affiliations

Mai Tram Vo: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Barbara J. Smith: Department of Cell Biology, Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine
John Nicholas: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Young Bong Choi: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-11164-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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Impaired removal of damaged mitochondria by mitophagy can activate innate immune signaling, but impact on virus replication remains unclear. Here the authors show that viral IRF-1 of human herpesvirus 8 activates mitophagy via interaction with the mitophagy receptor NIX and that vIRF-1 induced mitophagy supports productive infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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