Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life

Abstract

Background/Objectives: Hemophilia A is an X-linked recessive illness produced by a deficiency of coagulation factor VIII. This study aimed to evaluate serum vitamin D in hemophilic pediatric patients and its correlation with joint health and quality of life. Methods: This case-control study was performed on ninety children under the age of 18 years old and separated into two groups: study group of 45 children with hemophilia A and control group of 45 healthy children at an outpatient pediatric hematology clinic at the Beni-Suef University hospitals. Results: Serum vitamin D levels were significantly lower in hemophilia A patients than in controls (p p = 0.038) and serum vitamin D level (R = −0.974, p p p p-value lower than 0.001), alkaline phosphatase (R = 0.842, p p Conclusions: patients with hemophilia A had lower vitamin D levels than healthy controls. The severity of vitamin D deficiency is related positively to (HJHS) hemophilia and quality of life hemophilia cases according to Haemo-QoL.

Keywords

• hemophilia A
• vitamin D
• HJHS
• Haemo-Qol