Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner

Kun Wang; Muyun Wang; Ximing Liao; Shaoyong Gao; Jing Hua; Xiaodong Wu; Qian Guo; Wujian Xu; Jiaxing Sun; Yanan He; Qiang Li; Wei Gao

doi:10.1038/s41467-022-35492-y

Nature Communications (Dec 2022)

Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner

Kun Wang,
Muyun Wang,
Ximing Liao,
Shaoyong Gao,
Jing Hua,
Xiaodong Wu,
Qian Guo,
Wujian Xu,
Jiaxing Sun,
Yanan He,
Qiang Li,
Wei Gao

Affiliations

Kun Wang: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Muyun Wang: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Ximing Liao: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Shaoyong Gao: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Jing Hua: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Xiaodong Wu: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Qian Guo: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Wujian Xu: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Jiaxing Sun: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Yanan He: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Qiang Li: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine
Wei Gao: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-35492-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Acute respiratory distress syndrome (ARDS) is an acute pulmonary disease involving neutrophils. Here the authors characterise lung neutrophil infiltration during ARDS and show that there are neutrophils with different function and transcriptional profile which are regulated by IL-10.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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