Omega-3 polyunsaturated fatty acids as a pregravidar preparation

Abstract

I.Yu. Ilyina, Yu.E. Dobrokhotova Pirogov Russian National Research Medical University, Moscow, Russian Federation Aim: to study the effect of omega-3 polyunsaturated fatty acids (PUFA) supplement on the balance of fatty acids in female pregravidar preparation. Patients and Methods: the study included 42 female patients of the reproductive age who were planning pregnancy in the nearest future. The main group consisted of 24 female patients who took a drug containing omega-3 PUFA 585 mg for the pregravidar preparation. The control group included 18 female patients who took drugs containing folic acid 400 µg in a daily dose, iodine 200 µg, vitamin D 2000 U. The follow-up period of female patients and results control of the laboratory parameters during the treatment was 3 months. Then, the follow-up was based on the results of the reproductive performance implementation in a year. Results: during the therapy, omega-3 PUFA intake leaded to a slight increase of the fatty acids (FA) content, i.e., to the normalization of this indicator, which didn't not require constant control of the FA level and did not limit the time of use. Besides, when omega-3 PUFA was prescribed, the frequency of inevitable miscarriage might decrease (OR 2.6, 95% CI 1.2–14.7), however, this statement requires further study and confirmation in a larger number of female patients. Conclusion: the additional prescription of omega-3 PUFA for the pregravidar preparation has a positive effect. At the same time, routine determination of the fatty acids level and its control during the intake is not required before the prescription. The intake of omega-3 PUFA during pregnancy and in the early neonatal period is important for the subsequent normal functioning of the child's body. Keywords: pregravidar preparation, miscarriage, polyunsaturated fatty acids, omega-3 PUFA, fatty acids, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, oleic acid, nervonic acid, vitamin E, folic acid. For citation: Ilyina I.Yu., Dobrokhotova Yu.E. omega-3 polyunsaturated fatty acids as a pregravidar preparation. Russian Journal of Woman and Child Health. 2023;6(3):233–240 (in Russ.). DOI: 10.32364/2618-8430-2023-6-3-3.