Nature Communications (May 2017)
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
- Yadav Sapkota,
- Valgerdur Steinthorsdottir,
- Andrew P. Morris,
- Amelie Fassbender,
- Nilufer Rahmioglu,
- Immaculata De Vivo,
- Julie E. Buring,
- Futao Zhang,
- Todd L. Edwards,
- Sarah Jones,
- Dorien O,
- Daniëlle Peterse,
- Kathryn M. Rexrode,
- Paul M. Ridker,
- Andrew J. Schork,
- Stuart MacGregor,
- Nicholas G. Martin,
- Christian M. Becker,
- Sosuke Adachi,
- Kosuke Yoshihara,
- Takayuki Enomoto,
- Atsushi Takahashi,
- Yoichiro Kamatani,
- Koichi Matsuda,
- Michiaki Kubo,
- Gudmar Thorleifsson,
- Reynir T. Geirsson,
- Unnur Thorsteinsdottir,
- Leanne M. Wallace,
- iPSYCH-SSI-Broad Group,
- Jian Yang,
- Digna R. Velez Edwards,
- Mette Nyegaard,
- Siew-Kee Low,
- Krina T. Zondervan,
- Stacey A. Missmer,
- Thomas D'Hooghe,
- Grant W. Montgomery,
- Daniel I. Chasman,
- Kari Stefansson,
- Joyce Y. Tung,
- Dale R. Nyholt
Affiliations
- Yadav Sapkota
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Valgerdur Steinthorsdottir
- deCODE Genetics/Amgen, 101
- Andrew P. Morris
- Department of Biostatistics, University of Liverpool
- Amelie Fassbender
- Department of Development and Regeneration, KULeuven, Organ systems
- Nilufer Rahmioglu
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Immaculata De Vivo
- Harvard T.H. Chan School of Public Health
- Julie E. Buring
- Harvard T.H. Chan School of Public Health
- Futao Zhang
- Institute for Molecular Bioscience, The University of Queensland
- Todd L. Edwards
- Institute of Medicine and Public Health, Vanderbilt University Medical Center
- Sarah Jones
- Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Institute of Medicine and Public Health, Vanderbilt University Medical Center
- Dorien O
- Department of Development and Regeneration, KULeuven, Organ systems
- Daniëlle Peterse
- Department of Development and Regeneration, KULeuven, Organ systems
- Kathryn M. Rexrode
- Harvard T.H. Chan School of Public Health
- Paul M. Ridker
- Harvard T.H. Chan School of Public Health
- Andrew J. Schork
- Cognitive Science Department, University of California
- Stuart MacGregor
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Nicholas G. Martin
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Christian M. Becker
- Endometriosis CaRe Centre, Nuffield Dept of Obstetrics & Gynaecology, University of Oxford, John Radcliffe Hospital
- Sosuke Adachi
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Kosuke Yoshihara
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Takayuki Enomoto
- Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
- Atsushi Takahashi
- Center for Integrative Medical Sciences, RIKEN
- Yoichiro Kamatani
- Center for Integrative Medical Sciences, RIKEN
- Koichi Matsuda
- Institute of Medical Sciences, The University of Tokyo
- Michiaki Kubo
- Center for Integrative Medical Sciences, RIKEN
- Gudmar Thorleifsson
- deCODE Genetics/Amgen, 101
- Reynir T. Geirsson
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen, 101
- Leanne M. Wallace
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- iPSYCH-SSI-Broad Group
- Jian Yang
- Institute for Molecular Bioscience, The University of Queensland
- Digna R. Velez Edwards
- Department of Obstetrics and Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute of Medicine and Public Health, Vanderbilt University Medical Center
- Mette Nyegaard
- Department of Biomedicine, Aarhus University
- Siew-Kee Low
- Center for Integrative Medical Sciences, RIKEN
- Krina T. Zondervan
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Stacey A. Missmer
- Harvard T.H. Chan School of Public Health
- Thomas D'Hooghe
- Department of Development and Regeneration, KULeuven, Organ systems
- Grant W. Montgomery
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Daniel I. Chasman
- Harvard T.H. Chan School of Public Health
- Kari Stefansson
- deCODE Genetics/Amgen, 101
- Joyce Y. Tung
- 23andMe, Inc.
- Dale R. Nyholt
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- DOI
- https://doi.org/10.1038/ncomms15539
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis.
