Cardiac Involvement in Autosomal Dominant Polycystic Kidney Disease

Abstract

Cardiovascular disorders are the main complication in autosomal dominant polycystic kidney disease (ADPKD). contributing to both morbidity and mortality. This review considers clinical studies unveiling cardiovascular features in patients with ADPKD. Additionally, it focuses on basic science studies addressing the dysfunction of the polycystin proteins located in the cardiovascular system as a contributing factor to cardiovascular abnormalities. In particular, the effects of polycystin proteins’ deficiency on the cardiomyocyte function have been considered.

Keywords

• autosomal dominant polycystic kidney disease
• polycystin
• cardiomyocyte function
• left ventricular diastolic function