Mesenchymal-endothelial nexus in breast cancer spheroids induces vasculogenesis and local invasion in a CAM model

Aijun Li; Simone Muenst; Julius Hoffman; Laurent Starck; Melika Sarem; Andreas Fischer; Gregor Hutter; V. Prasad Shastri

doi:10.1038/s42003-022-04236-5

Communications Biology (Nov 2022)

Mesenchymal-endothelial nexus in breast cancer spheroids induces vasculogenesis and local invasion in a CAM model

Aijun Li,
Simone Muenst,
Julius Hoffman,
Laurent Starck,
Melika Sarem,
Andreas Fischer,
Gregor Hutter,
V. Prasad Shastri

Affiliations

Aijun Li: Institute for Macromolecular Chemistry, University of Freiburg
Simone Muenst: Institute for Medical Genetics and Pathology, University Hospital Basel
Julius Hoffman: Institute for Macromolecular Chemistry, University of Freiburg
Laurent Starck: Institute for Macromolecular Chemistry, University of Freiburg
Melika Sarem: Institute for Macromolecular Chemistry, University of Freiburg
Andreas Fischer: Institute for Clinical Chemistry, Göttingen University Hospital
Gregor Hutter: Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel
V. Prasad Shastri: Institute for Macromolecular Chemistry, University of Freiburg

DOI: https://doi.org/10.1038/s42003-022-04236-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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The interplay of mesenchymal and endothelial cells with breast cancer (BC) cells are investigated in a synthetic tumor microenvironment mimics (STEM) and CAM model to assess migration and metastasis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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