Military Medical Research (Dec 2022)
Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression
- Fei Pei,
- Ren-Qi Yao,
- Chao Ren,
- Soheyl Bahrami,
- Timothy R. Billiar,
- Irshad H. Chaudry,
- De-Chang Chen,
- Xu-Lin Chen,
- Na Cui,
- Xiang-Ming Fang,
- Yan Kang,
- Wei-Qin Li,
- Wen-Xiong Li,
- Hua-Ping Liang,
- Hong-Yuan Lin,
- Ke-Xuan Liu,
- Ben Lu,
- Zhong-Qiu Lu,
- Marc Maegele,
- Tian-Qing Peng,
- You Shang,
- Lei Su,
- Bing-Wei Sun,
- Chang-Song Wang,
- Jian Wang,
- Jiang-Huai Wang,
- Ping Wang,
- Jian-Feng Xie,
- Li-Xin Xie,
- Li-Na Zhang,
- Basilia Zingarelli,
- Xiang-Dong Guan,
- Jian-Feng Wu,
- Yong-Ming Yao,
- the Shock and Sepsis Society of Chinese Research Hospital Association,
- the China Critical Care Immunotherapy Research Group,
- the International Federation of the Shock Societies (IFSS)
Affiliations
- Fei Pei
- Department of Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University
- Ren-Qi Yao
- Translational Medicine Research Center, Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital
- Chao Ren
- Translational Medicine Research Center, Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital
- Soheyl Bahrami
- Ludwig-Boltzmann Institute for Experimental and Clinical Traumatology
- Timothy R. Billiar
- Department of Surgery, University of Pittsburgh Medical Center
- Irshad H. Chaudry
- Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham
- De-Chang Chen
- Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University
- Xu-Lin Chen
- Department of Burns, the First Affiliated Hospital of Anhui Medical University
- Na Cui
- Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College
- Xiang-Ming Fang
- Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine
- Yan Kang
- Department of Critical Care Medicine, West China Hospital of Sichuan University
- Wei-Qin Li
- Department of Critical Care Medicine, General Hospital of Eastern Theater Command of Chinese PLA
- Wen-Xiong Li
- Department of Surgical Intensive Critical Unit, Beijing Chao-Yang Hospital, Capital Medical University
- Hua-Ping Liang
- State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University
- Hong-Yuan Lin
- Department of Critical Care Medicine, Fourth Medical Center of the Chinese PLA General Hospital
- Ke-Xuan Liu
- Department of Anesthesiology, Nanfang Hospital, Southern Medical University
- Ben Lu
- Department of Critical Care Medicine and Hematology, the Third Xiangya Hospital, Central South University
- Zhong-Qiu Lu
- Emergency Department, the First Affiliated Hospital of Wenzhou Medical University
- Marc Maegele
- Department of Traumatology and Orthopedic Surgery, University Witten-Herdecke
- Tian-Qing Peng
- Critical Illness Research, Lawson Health Research Institute, London Health Sciences Centre
- You Shang
- Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology
- Lei Su
- Department of Intensive Care Unit, General Hospital of Southern Theater Command of Chinese PLA
- Bing-Wei Sun
- Department of Burns and Plastic Surgery, Affiliated Suzhou Hospital of Nanjing Medical University
- Chang-Song Wang
- Department of Critical Care Medicine, Harbin Medical University Cancer Hospital
- Jian Wang
- Children’s Hospital of Soochow University, Pediatric Research Institute of Soochow University
- Jiang-Huai Wang
- Department of Academic Surgery, University College Cork, Cork University Hospital
- Ping Wang
- Center for Immunology and Inflammation, the Feinstein Institute for Medical Research, Northwell Health
- Jian-Feng Xie
- Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University
- Li-Xin Xie
- Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital
- Li-Na Zhang
- Department of Critical Care Medicine, Xiangya Hospital, Central South University
- Basilia Zingarelli
- Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center
- Xiang-Dong Guan
- Department of Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University
- Jian-Feng Wu
- Department of Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University
- Yong-Ming Yao
- Translational Medicine Research Center, Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital
- the Shock and Sepsis Society of Chinese Research Hospital Association
- the China Critical Care Immunotherapy Research Group
- the International Federation of the Shock Societies (IFSS)
- DOI
- https://doi.org/10.1186/s40779-022-00430-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Abstract Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed. Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed, Web of Science, and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire. Then, the Delphi method was used to form consensus opinions, and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions. This consensus achieved satisfactory results through two rounds of questionnaire survey, with 2 statements rated as perfect consistency, 13 as very good consistency, and 9 as good consistency. After summarizing the results, a total of 14 strong recommended opinions, 8 weak recommended opinions and 2 non-recommended opinions were produced. Finally, a face-to-face discussion of the consensus opinions was performed through an online meeting, and all judges unanimously agreed on the content of this consensus. In summary, this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.
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