ANTIBIOTIC-RESISTANCE OF MICROBIAL FLORA ISOLATED FROM BIOPTATES MATERIAL FROM PATIENTS WITH ATHEROSCLEROSIS

Abstract

The sensitivity of strains of microorganisms isolated from bioptates of atherosclerotic plaques to different antimicrobials was studied. For this study, the samples of atherosclerotic plaques from a group of patients that underwent elective carotid endarterectomy were used. Among 137 strains of coagulase-negative staphylococci 13.1 % of all isolates were methicillin-resistant, but all were sensitive to vancomycin, linezolid and moxifloxacin. Some strains of staphylococci possessed the resistance to erythromycin and tetracycline (16.3 %) and (13.9 %) respectively. The greatest resistance among coagulase-negative staphylococci to chloramphenicol (43.4 %) were identified. The high sensitivity of such bacteria to clindamycin, ciprofloxacin and gentamycin (92.6, 92.0 and 90.5 % respectively) were established. Among 197 isolates of Propionibacterium acnes all strains were highly sensitive to all antibiotics (amoxicillin, amoxicillin-clavulanic acid, benzylpenicillin, imipenem, clindamycin, piperacyllin, piperacyllin/tazobactam, ticarcillin, ticarcillin-clavulanic acid, chloramphenicol amd cefoxitin) which were tested. As exception was a metronidazole resistance to which bacteria are naturally refractory. The data obtained confirm that only small part of coagulase-negative staphylococci possessed the resistance to methicillin (13.1 %), but many among them demonstrated a high level of resistance to chloramphenicol. Between the strains of propionibacteria the acquired resistance to different antibacterials was not revealed.

Keywords

• atherosclerotic plaques
• coagulase-negative staphylococci
• propionibacterium
• antibiotics sensitivity