Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors

Alexey Bingor; Tomer Haham; Claire Thornton; Yael Stern-Bach; Rami Yaka

doi:10.1038/s41467-020-17484-y

Nature Communications (Jul 2020)

Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors

Alexey Bingor,
Tomer Haham,
Claire Thornton,
Yael Stern-Bach,
Rami Yaka

Affiliations

Alexey Bingor: Institute for Drug Research (IDR), School of Pharmacy, The Hebrew University of Jerusalem
Tomer Haham: Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem
Claire Thornton: Department of Comparative Biomedical Sciences, Royal Veterinary College
Yael Stern-Bach: Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem
Rami Yaka: Institute for Drug Research (IDR), School of Pharmacy, The Hebrew University of Jerusalem

DOI: https://doi.org/10.1038/s41467-020-17484-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

Zeta inhibitory peptide (ZIP) impairs the maintenance of acquired memories. ZIP is known as an inhibitor of PKMζ. Here, the authors unveil how ZIP impairs memory maintenance acting as an arginine donor, facilitating NO-dependent down-regulation of AMPARs, independently of its action on PKMζ.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal