Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration

Tianhong Wang; Susan Hamilla; Maggie Cam; Helim Aranda-Espinoza; Stavroula Mili

doi:10.1038/s41467-017-00884-y

Nature Communications (Oct 2017)

Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration

Tianhong Wang,
Susan Hamilla,
Maggie Cam,
Helim Aranda-Espinoza,
Stavroula Mili

Affiliations

Tianhong Wang: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH
Susan Hamilla: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH
Maggie Cam: CCR Collaborative Bioinformatics Resource, National Cancer Institute, NIH
Helim Aranda-Espinoza: Fischell Department of Bioengineering, University of Maryland
Stavroula Mili: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH

DOI: https://doi.org/10.1038/s41467-017-00884-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Adenomatous polyposis coli (APC) regulates the localization of some mRNAs at cellular protrusions but the underlying mechanisms and functional roles are not known. Here the authors show that APC-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules, and enhance cell migration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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