Modulation of Autophagy-Like Processes by Tumor Viruses

Abstract

Autophagy is an intracellular degradation pathway for long-lived proteins and organelles. This process is activated above basal levels upon cell intrinsic or environmental stress and dysregulation of autophagy has been linked to various human diseases, including those caused by viral infection. Many viruses have evolved strategies to directly interfere with autophagy, presumably to facilitate their replication or to escape immune detection. However, in some cases, modulation of autophagy appears to be a consequence of the virus disturbing the cell’s metabolic signaling networks. Here, we summarize recent advances in research at the interface of autophagy and viral infection, paying special attention to strategies that human tumor viruses have evolved.

Keywords

• autophagy
• cancer
• Epstein–Barr virus
• hepatitis B virus
• hepatitis C virus
• human papillomavirus
• human T-lymphotropic virus 1
• Kaposi’s sarcoma-associated herpesvirus
• Merkel cell polyomavirus