744 Single cell profiling of acute myeloid leukemia (AML) and its microenvironment reveals a CD8 continuum and adaptable T cell plasticity in response to PD-1 blockade-based therapy

• Feng Wang,
• Wei Wang,
• Michael Green,
• Ruiping Wang,
• Jianhua Zhang,
• Andrew Futreal,
• Jing Ning,
• James Allison,
• Padmanee Sharma,
• Marina Konopleva,
• Latasha Little,
• Hussein Abbas,
• Katarzyna Tomczak,
• Praveen Barrodia,
• Jin Seon Im,
• Patrick Reville,
• Zoe Alaniz,
• Gheath Al-Atrash,
• Koichi Takahashi,
• Maomao Ding,
• Jairo Matthews,
• Sreyashi Basu,
• Guillermo Garcia-Manero,
• Steven Kornblau,
• Kunal Rai,
• Naval Daver

Affiliations

Feng Wang

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Wei Wang

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

Michael Green

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Ruiping Wang

General office, Songjiang Center for Disease Control and Prevention, Shanghai, China

Jianhua Zhang

1 Genomic Medicine, UT MDACC, Houston, Texas, USA

Andrew Futreal

1 Genomic Medicine, UT MDACC, Houston, Texas, USA

Jing Ning

3 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

James Allison

Aff2 grid.240145.60000000122914776MD Anderson Cancer Center Houston TX USA

Padmanee Sharma

Aff4 grid.240145.60000000122914776MD Anderson Cancer Center Houston TX USA

Marina Konopleva

Aff2 0000 0001 2291 4776grid.240145.6Department of LeukemiaUniversity of Texas MD Anderson Cancer Center Houston TX USA

Latasha Little

Aff1 grid.240145.60000000122914776The University of Texas MD Anderson Cancer Center Houston TX USA

Hussein Abbas

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Katarzyna Tomczak

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Praveen Barrodia

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Jin Seon Im

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Patrick Reville

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Zoe Alaniz

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Gheath Al-Atrash

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Koichi Takahashi

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Maomao Ding

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Jairo Matthews

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Sreyashi Basu

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Guillermo Garcia-Manero

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Steven Kornblau

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Kunal Rai

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Naval Daver

The University of Texas MD Anderson Cancer Center, Houston, TX, USA