Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B

Simon Andrews; Christel Krueger; Maravillas Mellado-Lopez; Myriam Hemberger; Wendy Dean; Vicente Perez-Garcia; Courtney W. Hanna

doi:10.1038/s41467-023-36019-9

Nature Communications (Jan 2023)

Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B

Simon Andrews,
Christel Krueger,
Maravillas Mellado-Lopez,
Myriam Hemberger,
Wendy Dean,
Vicente Perez-Garcia,
Courtney W. Hanna

Affiliations

Simon Andrews: Bioinformatics Programme, Babraham Institute
Christel Krueger: Bioinformatics Programme, Babraham Institute
Maravillas Mellado-Lopez: Centro de Investigación Príncipe Felipe
Myriam Hemberger: Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary
Wendy Dean: Alberta Children’s Hospital Research Institute, University of Calgary
Vicente Perez-Garcia: Centro de Investigación Príncipe Felipe
Courtney W. Hanna: Epigenetics Programme, Babraham Institute

DOI: https://doi.org/10.1038/s41467-023-36019-9
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

Read online

DNA methylation is a repressive modification that is essential for development. Here the authors reveal a critical role for DNA methylation in placental development during pregnancy. Failure to properly establish placental DNA methylation patterns compromises not only placental function, but embryo survival.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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