3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression

D. Löb; N. Lengert; V. O. Chagin; M. Reinhart; C. S. Casas-Delucchi; M. C. Cardoso; B. Drossel

doi:10.1038/ncomms11207

Nature Communications (Apr 2016)

3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression

D. Löb,
N. Lengert,
V. O. Chagin,
M. Reinhart,
C. S. Casas-Delucchi,
M. C. Cardoso,
B. Drossel

Affiliations

D. Löb: Department of Physics, Institute for Condensed Matter Physics, Technische Universität Darmstadt
N. Lengert: Department of Physics, Institute for Condensed Matter Physics, Technische Universität Darmstadt
V. O. Chagin: Laboratory of Chromosome Stability, Institute of Cytology
M. Reinhart: Department of Biology, Technische Universität Darmstadt
C. S. Casas-Delucchi: Department of Biology, Technische Universität Darmstadt
M. C. Cardoso: Department of Biology, Technische Universität Darmstadt
B. Drossel: Department of Physics, Institute for Condensed Matter Physics, Technische Universität Darmstadt

DOI: https://doi.org/10.1038/ncomms11207
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

Read online

DNA replication in higher eukaryotes is a complex process occurring in a complex genome environment. Here the authors present a model of DNA replication that incorporates random loop chromatin folding and domino-like fork progression reproducing the spatial and temporal characteristics of S-phase.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal