Nature Communications (Dec 2017)
Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
Abstract
Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-specific inhibitors on Src dynamics.