Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of<em> Zingiber officinale</em>

Abstract

In the present study, the chemical investigation of the bioactive fractions of the rhizomes of <em>Zingiber officinale</em> has resulted in the identification of twenty-nine compounds including one new compound, <em>O</em>-methyldehydrogingerol (<strong>1</strong>). Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol (<strong>13</strong>) and [6]-shogaol (<strong>17</strong>) exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol (<strong>15</strong>) inhibited the Ca²⁺-dependent contractions in high K⁺ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism.

Keywords

• anti-platelet aggregation
• vasorelaxing
• Zingiberaceae
• gingerol
• shogaol