LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei

Jiang Zhu; Kang Chen; Yu H. Sun; Wen Ye; Juntao Liu; Dandan Zhang; Nan Su; Li Wu; Xiaochen Kou; Yanhong Zhao; Hong Wang; Shaorong Gao; Lan Kang

doi:10.1038/s41467-023-36584-z

Nature Communications (Feb 2023)

LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei

Jiang Zhu,
Kang Chen,
Yu H. Sun,
Wen Ye,
Juntao Liu,
Dandan Zhang,
Nan Su,
Li Wu,
Xiaochen Kou,
Yanhong Zhao,
Hong Wang,
Shaorong Gao,
Lan Kang

Affiliations

Jiang Zhu: Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University
Kang Chen: Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University
Yu H. Sun: Departments of Biology, University of Rochester
Wen Ye: Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University
Juntao Liu: Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University
Dandan Zhang: Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University
Nan Su: Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University
Li Wu: Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, School of Life Sciences and Technology, Tongji University
Xiaochen Kou: Frontier Science Center for Stem Cell Research, Tongji University
Yanhong Zhao: Frontier Science Center for Stem Cell Research, Tongji University
Hong Wang: Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, School of Life Sciences and Technology, Tongji University
Shaorong Gao: Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University
Lan Kang: Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University

DOI: https://doi.org/10.1038/s41467-023-36584-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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Asymmetric histone modifications in parental pronuclei displays epigenetic regulation. Here the authors reveal the role of LSM1-mediated Major Satellite RNA decay in the H3 variant incorporation and modifications in male pronucleus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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