Nature Communications (Oct 2022)
Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+ dermatomyositis with therapeutic implications
- Yan Ye,
- Zechuan Chen,
- Shan Jiang,
- Fengyun Jia,
- Teng Li,
- Xia Lu,
- Jing Xue,
- Xinyue Lian,
- Jiaqiang Ma,
- Pei Hao,
- Liangjing Lu,
- Shuang Ye,
- Nan Shen,
- Chunde Bao,
- Qiong Fu,
- Xiaoming Zhang
Affiliations
- Yan Ye
- Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Zechuan Chen
- The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Shan Jiang
- The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Fengyun Jia
- The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Teng Li
- The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Xia Lu
- Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Jing Xue
- Department of Rheumatology, the Second Affiliated Hospital of Zhejiang University School of Medicine
- Xinyue Lian
- Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Jiaqiang Ma
- The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Pei Hao
- The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Liangjing Lu
- Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Shuang Ye
- Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Nan Shen
- Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Chunde Bao
- Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Qiong Fu
- Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Xiaoming Zhang
- The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-022-34145-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Anti-melanoma differentiation-associated gene 5-positive dermatomyositis is a severe autoimmune disease with largely unknown aetiology. Here authors identify the key immune cell types that contribute to the disease phenotype and implicate type I interferons signalling in the patho-mechanism.
