Cancers (Jun 2022)
Environmental Contaminants Modulate Breast Cancer Development and Outcome in <i>TP53</i> p.R337H Carriers and Noncarriers
- Viviane K. Q. Gerber,
- Mariana M. Paraizo,
- Humberto C. Ibañez,
- José C. Casali-da-Rocha,
- Emilia M. Pinto,
- Diancarlos P. Andrade,
- Marilea V. C. Ibañez,
- Heloisa Komechen,
- Mirna M. O. Figueiredo,
- Gislaine Custódio,
- Carmem M. C. M. Fiori,
- José H. G. Balbinotti,
- Jeanine M. Nardin,
- Thais A. Almeida,
- Olair O. Beltrame,
- Paula A. Yamada,
- Gabriel S. de Fraga,
- Lucas L. de Brito,
- Jamylle Martins,
- Viviane S. Melanda,
- Otavio A. B. Licht,
- Victoria Z. Teixeira,
- Sandy K. S. Pinho,
- Silvia Bottini,
- Enzo Lalli,
- Gerard P. Zambetti,
- Bonald C. Figueiredo
Affiliations
- Viviane K. Q. Gerber
- Pelé Pequeno Príncipe Research Institute, Avenida Silva Jardim, 1632, Água Verde, Curitiba 80250-200, PR, Brazil
- Mariana M. Paraizo
- Pelé Pequeno Príncipe Research Institute, Avenida Silva Jardim, 1632, Água Verde, Curitiba 80250-200, PR, Brazil
- Humberto C. Ibañez
- Pelé Pequeno Príncipe Research Institute, Avenida Silva Jardim, 1632, Água Verde, Curitiba 80250-200, PR, Brazil
- José C. Casali-da-Rocha
- Erasto Gaertner Hospital, Rua Dr. Ovande do Amaral, 201, Jardim das Américas, Curitiba 81520-060, PR, Brazil
- Emilia M. Pinto
- Department of Pathology, St. Jude Children’s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA
- Diancarlos P. Andrade
- Pelé Pequeno Príncipe Research Institute, Avenida Silva Jardim, 1632, Água Verde, Curitiba 80250-200, PR, Brazil
- Marilea V. C. Ibañez
- Pelé Pequeno Príncipe Research Institute, Avenida Silva Jardim, 1632, Água Verde, Curitiba 80250-200, PR, Brazil
- Heloisa Komechen
- Pelé Pequeno Príncipe Research Institute, Avenida Silva Jardim, 1632, Água Verde, Curitiba 80250-200, PR, Brazil
- Mirna M. O. Figueiredo
- Centro de Genética Molecular e Pesquisa do Câncer em Crianças-CEGEMPAC, Universidade Federal do Paraná, Avenida Agostinho Leão Junior, 400, Alto da Glória, Curitiba 80030-110, PR, Brazil
- Gislaine Custódio
- Centro de Genética Molecular e Pesquisa do Câncer em Crianças-CEGEMPAC, Universidade Federal do Paraná, Avenida Agostinho Leão Junior, 400, Alto da Glória, Curitiba 80030-110, PR, Brazil
- Carmem M. C. M. Fiori
- União Oeste Paranaense de Estudos e Combate ao Câncer–UOPECCAN, Rua Itaquatiaras 769, Santo Onofre, Cascavel 85.806-300, PR, Brazil
- José H. G. Balbinotti
- Pelé Pequeno Príncipe Research Institute, Avenida Silva Jardim, 1632, Água Verde, Curitiba 80250-200, PR, Brazil
- Jeanine M. Nardin
- Erasto Gaertner Hospital, Rua Dr. Ovande do Amaral, 201, Jardim das Américas, Curitiba 81520-060, PR, Brazil
- Thais A. Almeida
- Erasto Gaertner Hospital, Rua Dr. Ovande do Amaral, 201, Jardim das Américas, Curitiba 81520-060, PR, Brazil
- Olair O. Beltrame
- Erasto Gaertner Hospital, Rua Dr. Ovande do Amaral, 201, Jardim das Américas, Curitiba 81520-060, PR, Brazil
- Paula A. Yamada
- Erasto Gaertner Hospital, Rua Dr. Ovande do Amaral, 201, Jardim das Américas, Curitiba 81520-060, PR, Brazil
- Gabriel S. de Fraga
- Erasto Gaertner Hospital, Rua Dr. Ovande do Amaral, 201, Jardim das Américas, Curitiba 81520-060, PR, Brazil
- Lucas L. de Brito
- Erasto Gaertner Hospital, Rua Dr. Ovande do Amaral, 201, Jardim das Américas, Curitiba 81520-060, PR, Brazil
- Jamylle Martins
- Erasto Gaertner Hospital, Rua Dr. Ovande do Amaral, 201, Jardim das Américas, Curitiba 81520-060, PR, Brazil
- Viviane S. Melanda
- Departamento de Vigilância Epidemiológica, Secretaria do Estado da Saúde do Paraná, Rua Piquiri, 17, Rebouças, Curitiba 80230-140, PR, Brazil
- Otavio A. B. Licht
- Instituto de Terras, Cartografia e Geologia, Rua Desembargador Motta, 338, Mercês, Curitiba 80430-232, PR, Brazil
- Victoria Z. Teixeira
- Universidade Estadual do Centro-Oeste, UNICENTRO, Alameda Élio Antonio Dalla Vecchia, 838, Vila Carli, Guarapuava 85040-167, PR, Brazil
- Sandy K. S. Pinho
- Universidade Estadual do Centro-Oeste, UNICENTRO, Alameda Élio Antonio Dalla Vecchia, 838, Vila Carli, Guarapuava 85040-167, PR, Brazil
- Silvia Bottini
- Center of Modeling, Simulation & Interaction, Université Côte d’Azur, 1361 Route des Lucioles, 06560 Valbonne, France
- Enzo Lalli
- Institut de Pharmacologie Moléculaire et Cellulaire CNRS, Valbonne, 660 Route des Lucioles, 06560 Valbonne, France
- Gerard P. Zambetti
- Department of Pathology, St. Jude Children’s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA
- Bonald C. Figueiredo
- Pelé Pequeno Príncipe Research Institute, Avenida Silva Jardim, 1632, Água Verde, Curitiba 80250-200, PR, Brazil
- DOI
- https://doi.org/10.3390/cancers14123014
- Journal volume & issue
-
Vol. 14,
no. 12
p. 3014
Abstract
Two major concerns associated with cancer development in Paraná state, South Brazil, are environmental pollution and the germline TP53 p.R337H variant found in 0.27–0.30% of the population. We assessed breast cancer (BC) risk in rural (C1 and C2) and industrialized (C3) subregions, previously classified by geochemistry, agricultural productivity, and population density. C2 presents lower organochloride levels in rivers and lower agricultural outputs than C1, and lower levels of chlorine anions in rivers and lower industrial activities than C3. TP53 p.R337H status was assessed in 4658 women aged >30 years from C1, C2, and C3, subsequent to a genetic screening (Group 1, longitudinal study). BC risk in this group was 4.58 times higher among TP53 p.R337H carriers. BC prevalence and risk were significantly lower in C2 compared to that in C3. Mortality rate and risk associated with BC in women aged >30 years (n = 8181 deceased women; Group 2) were also lower in C2 than those in C3 and C1. These results suggest that environmental factors modulate BC risk and outcome in carriers and noncarriers.
Keywords