Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages

Shaon Chakrabarti; Andrew L. Paek; Jose Reyes; Kathleen A. Lasick; Galit Lahav; Franziska Michor

doi:10.1038/s41467-018-07788-5

Nature Communications (Dec 2018)

Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages

Shaon Chakrabarti,
Andrew L. Paek,
Jose Reyes,
Kathleen A. Lasick,
Galit Lahav,
Franziska Michor

Affiliations

Shaon Chakrabarti: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute
Andrew L. Paek: Department of Systems Biology, Blavatnik Institute, Harvard Medical School
Jose Reyes: Department of Systems Biology, Blavatnik Institute, Harvard Medical School
Kathleen A. Lasick: University of Arizona
Galit Lahav: Department of Systems Biology, Blavatnik Institute, Harvard Medical School
Franziska Michor: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute

DOI: https://doi.org/10.1038/s41467-018-07788-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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The origins of lineage correlations and heterogeneity in division and apoptosis times among single cells are incompletely understood. Here, a new lineage tracking data analysis approach reveals that circadian oscillations may underlie cell fate control and explain the observed correlation structures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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