Assessment of Retinal Volume in Individuals Without Ocular Disorders Based on Wide-Field Swept-Source OCT

Abstract

Purpose: To evaluate retinal volume (RV) in eyes without retinal disease using wide-field swept-source OCT (SS-OCT). Design: Observational, cross-sectional design. Participants: A total of 332 eyes of 166 healthy participants. Methods: The eyes were imaged with OCT-S1 (Canon) using a protocol centered on the fovea cube scans (20 × 23 mm) of SS-OCT images. Retinal volume (6-mm circle, 6–20-mm ring) and various parameters were evaluated in a multivariate analysis using a generalized estimating equation model. Each quadrant of the macula except for the fovea (1–6 mm in diameter) and peripheral ring (6–20 mm in diameter) was also evaluated. Main Outcome Measures: Retinal volume. Results: In the multivariate analysis, older age and longer axial length were associated with smaller macular RV, whereas older age and left eye were associated with smaller peripheral RV. The temporal area was significantly smaller than all other areas in the macula (1–6 mm), whereas the inferior area was significantly smaller than all other areas in the peripheral retina (6–20 mm). Conclusions: In wide-field SS-OCT images, age and left eye are negatively correlated with peripheral RV. The thinnest part of the retinal quadrant differs between the macular and peripheral retinas. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Keywords

• Macula
• Peripheral retina
• Retinal volume
• Swept-source OCT