Nature Communications (Jul 2019)

Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity

  • Martim Dias Gomes,
  • Soriba Letzian,
  • Michael Saynisch,
  • Sandra Iden

DOI
https://doi.org/10.1038/s41467-019-11325-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Many developing tissues require Par-driven polarization, but its role in mammalian tissue maintenance is unclear. Here, the authors show that in mouse epidermis, Par3 governs tissue homeostasis not via orientation of cell division but by coupling cell mechanics with mitotic accuracy and genome integrity.