Global gene expression analysis for evaluation and design of biomaterials

Science and Technology of Advanced Materials. 2010;11(1):013001

 

Journal Homepage

Journal Title: Science and Technology of Advanced Materials

ISSN: 1468-6996 (Print); 1878-5514 (Online)

Publisher: National Institute for Materials Science

Society/Institution: National Institute for Materials Science

LCC Subject Category: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials | Technology: Chemical technology: Biotechnology

Country of publisher: Japan

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Nobutaka Hanagata, Taro Takemura and Takashi Minowa

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 15 weeks

 

Abstract | Full Text

Comprehensive gene expression analysis using DNA microarrays has become a widespread technique in molecular biological research. In the biomaterials field, it is used to evaluate the biocompatibility or cellular toxicity of metals, polymers and ceramics. Studies in this field have extracted differentially expressed genes in the context of differences in cellular responses among multiple materials. Based on these genes, the effects of materials on cells at the molecular level have been examined. Expression data ranging from several to tens of thousands of genes can be obtained from DNA microarrays. For this reason, several tens or hundreds of differentially expressed genes are often present in different materials. In this review, we outline the principles of DNA microarrays, and provide an introduction to methods of extracting information which is useful for evaluating and designing biomaterials from comprehensive gene expression data.