Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease

Gert T. Verhoeven; Ingrid M. Garrelds; Henk C. Hoogsteden; Freek J. Zijlstra

doi:10.1080/09629350123056

Mediators of Inflammation (Jan 2001)

Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease

Gert T. Verhoeven,
Ingrid M. Garrelds,
Henk C. Hoogsteden,
Freek J. Zijlstra

Affiliations

Gert T. Verhoeven: Department of Pulmonary and Intensive Care Medicine, University Hospital Dijkzigt and Erasmus University, EMCR, Rotterdam, The Netherlands
Ingrid M. Garrelds: Department of Pharmacology, University Hospital Dijkzigt and Erasmus University, EMCR, Rotterdam, The Netherlands
Henk C. Hoogsteden: Department of Pulmonary and Intensive Care Medicine, University Hospital Dijkzigt and Erasmus University, EMCR, Rotterdam, The Netherlands
Freek J. Zijlstra: Department of Anesthesiology, University Hospital Dijkzigt and Erasmus University, EMCR, Rotterdam, The Netherlands

DOI: https://doi.org/10.1080/09629350123056
Journal volume & issue: Vol. 10, no. 1
pp. 21 – 26

Abstract

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Background: In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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