A critical bioenergetic switch is regulated by IGF2 during murine cartilage development

Judith M. Hollander; Lingyun Li; Miraj Rawal; Si Kun Wang; Yue Shu; Ming Zhang; Heber C. Nielsen; Clifford J. Rosen; Li Zeng

doi:10.1038/s42003-022-04156-4

Communications Biology (Nov 2022)

A critical bioenergetic switch is regulated by IGF2 during murine cartilage development

Judith M. Hollander,
Lingyun Li,
Miraj Rawal,
Si Kun Wang,
Yue Shu,
Ming Zhang,
Heber C. Nielsen,
Clifford J. Rosen,
Li Zeng

Affiliations

Judith M. Hollander: Program in Cell, Molecular and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University
Lingyun Li: Department of Immunology, Tufts University School of Medicine
Miraj Rawal: Department of Immunology, Tufts University School of Medicine
Si Kun Wang: Department of Immunology, Tufts University School of Medicine
Yue Shu: Department of Immunology, Tufts University School of Medicine
Ming Zhang: Department of Computer Science, Boston University
Heber C. Nielsen: Program in Cell, Molecular and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University
Clifford J. Rosen: Center for Molecular Medicine, Maine Medical Center Research Institute
Li Zeng: Program in Cell, Molecular and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University

DOI: https://doi.org/10.1038/s42003-022-04156-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Murine chondrocyte hypertrophy was found to require IGF2-regulated bioenergetic reprogramming, in which glucose utilization shifts from glycolysis to oxidative phosphorylation as chondrocytes mature.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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