Frontiers in Neuroscience (Jun 2023)
Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons
- Qingping Zhang,
- Qingping Zhang,
- Qingping Zhang,
- Wei Jing,
- Wei Jing,
- Wei Jing,
- Shiping Wu,
- Shiping Wu,
- Shiping Wu,
- Mengzheng Zhu,
- Mengzheng Zhu,
- Mengzheng Zhu,
- Jingrui Jiang,
- Jingrui Jiang,
- Jingrui Jiang,
- Xiang Liu,
- Xiang Liu,
- Xiang Liu,
- Dian Yu,
- Dian Yu,
- Dian Yu,
- Long Cheng,
- Long Cheng,
- Long Cheng,
- Bin Feng,
- Bin Feng,
- Jianbin Wen,
- Jianbin Wen,
- Jianbin Wen,
- Feng Xiong,
- Youming Lu,
- Youming Lu,
- Youming Lu,
- Huiyun Du,
- Huiyun Du,
- Huiyun Du
Affiliations
- Qingping Zhang
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Qingping Zhang
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Qingping Zhang
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Wei Jing
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Wei Jing
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Wei Jing
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Shiping Wu
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Shiping Wu
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Shiping Wu
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Mengzheng Zhu
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Mengzheng Zhu
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Mengzheng Zhu
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Jingrui Jiang
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jingrui Jiang
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Jingrui Jiang
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Xiang Liu
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xiang Liu
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Xiang Liu
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Dian Yu
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Dian Yu
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Dian Yu
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Long Cheng
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Long Cheng
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Long Cheng
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Bin Feng
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Bin Feng
- Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jianbin Wen
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jianbin Wen
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Jianbin Wen
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Feng Xiong
- Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, National Center for Magnetic Resonance in Wuhan, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China
- Youming Lu
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Youming Lu
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Youming Lu
- Department of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
- Huiyun Du
- Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Huiyun Du
- Wuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China
- Huiyun Du
- Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, Wuhan, China
- DOI
- https://doi.org/10.3389/fnins.2023.1195095
- Journal volume & issue
-
Vol. 17
Abstract
The investigation of brain networks and neural circuits involves the crucial aspects of observing and modulating neurophysiological activity. Recently, opto-electrodes have emerged as an efficient tool for electrophysiological recording and optogenetic stimulation, which has greatly facilitated the analysis of neural coding. However, implantation and electrode weight control have posed significant challenges in achieving long-term and multi-regional brain recording and stimulation. To address this issue, we have developed a mold and custom-printed circuit board-based opto-electrode. We report successful opto-electrode placement and high-quality electrophysiological recordings from the default mode network (DMN) of the mouse brain. This novel opto-electrode facilitates synchronous recording and stimulation in multiple brain regions and holds promise for advancing future research on neural circuits and networks.
Keywords
- electrophysiological recording
- optogenetic
- multichannel recording
- default mode network
- brain network
- neural circuit
