Effect of Probiotic Therapy on Clinical-Biochemical and Instrumental Parameters of Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

Abstract

We examined 72 patients with type 2 diabetes mellitus (DM) and nonalcoholic fatty liver disease (NAFLD). According to course of therapy all patients were divided into two groups. Patients of the main group (n = 45) received oral hypoglycemic agents and multiprobiotic symbiter within 30 days. To assess the functional state of the liver we studied protein, pigment, enzyme and lipid metabolism. All patients underwent ultrasound examination, including shear wave elastography. The efficacy of using multiprobiotic symbiter acidophilic concentrated in patients with DM type 2 and NAFLD has been proved. With increasing transaminases, hepatoprotective effect is a decrease of their levels in the blood, inflammatory and necrotic changes in the liver parenchyma. In patients with normal transaminases, hypolipidemic and antisteatogenic effects of multiprobiotic are present.

Keywords

• diabetes mellitus type 2
• nonalcoholic fatty liver disease
• multyprobiotic symbiter