Nature Communications (Mar 2019)
Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci
- Tom Dudding,
- Simon Haworth,
- Penelope A. Lind,
- J. Fah Sathirapongsasuti,
- 23andMe Research Team,
- Joyce Y. Tung,
- Ruth Mitchell,
- Lucía Colodro-Conde,
- Sarah E. Medland,
- Scott Gordon,
- Benjamin Elsworth,
- Lavinia Paternoster,
- Paul W. Franks,
- Steven J. Thomas,
- Nicholas G. Martin,
- Nicholas J. Timpson
Affiliations
- Tom Dudding
- Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- Simon Haworth
- Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- Penelope A. Lind
- Department of Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- J. Fah Sathirapongsasuti
- Research, 23andMe, Inc
- 23andMe Research Team
- Joyce Y. Tung
- Research, 23andMe, Inc
- Ruth Mitchell
- Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- Lucía Colodro-Conde
- Department of Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- Sarah E. Medland
- Department of Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- Scott Gordon
- Department of Genetic Epidemiology, QIMR Berghofer Medical Research Institute
- Benjamin Elsworth
- Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- Lavinia Paternoster
- Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- Paul W. Franks
- Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University
- Steven J. Thomas
- Bristol Dental School, University of Bristol
- Nicholas G. Martin
- Department of Genetic Epidemiology, QIMR Berghofer Medical Research Institute
- Nicholas J. Timpson
- Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
- DOI
- https://doi.org/10.1038/s41467-019-08923-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Oral ulcerations are sores of the mucous membrane of the mouth and highly prevalent in the population. Here, in a genome-wide association study, the authors identify 97 loci associated with mouth ulcers highlighting genes involved in T cell-mediated immunity and TH1 responses.
