Heliyon (Apr 2023)

Epidemiological and clinical features of hypertrophic scar and keloid in Chinese college students: A university-based cross-sectional survey

  • An-Hao Liu,
  • Xiao-Lu Sun,
  • Di-Zhi Liu,
  • Fan Xu,
  • Shi-Jie Feng,
  • Shi-Yu Zhang,
  • Lu-Zhou Li,
  • Jia-Li Zhou,
  • Yi-Ting Wang,
  • Li Zhang,
  • Xiao Lin,
  • Shu-Bin Gao,
  • Xin Yue,
  • Xiao-Ming Liu,
  • Guang-Hui Jin,
  • Bin Xu

Journal volume & issue
Vol. 9, no. 4
p. e15345

Abstract

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Background: Hypertrophic scar (HS) and keloid (KD) are common dermal fibroproliferative growth caused by pathological wound healing. HS's prevalence is currently undetermined in China. Though it primarily occurs in dark-skinned individuals, KD can develop in all races, and its prevalence among Chinese people is poorly documented. Objective: To explore the present epidemiological status of them in Chinese college students. Methods: We conducted a university-based cross-sectional study at one university in Fujian, China. A total of 1785 participants aged 16–34 years (mean age, 20.0 ± 2.0; 58.7% female) were enrolled and statistical analyses were performed. Results: HS and KD were observed in 5.2% (95% confidence interval [CI]: 4.2–6.2) and 0.6% (95% CI: 0.3–1.0) of the population respectively. There was a significant difference by sex in HS (P < 0.05), but not in KD. The prevalence of HS and KD both showed a significant difference by age (P < 0.05), but not in ethnic and native place distribution. The occurrence of HS and KD were both concentrated in individuals 9–20 years old (HS: 77.2%; KD: 81.8%). They were mainly distributed in the upper limbs (52.1%; 64.3%), and the main cause was trauma (51.0%; 35.7%). In addition, male sex was a risk factor for HS (adjusted P < 0.001), and KD was associated with age ≥22 years and family history (adjusted P < 0.050). Conclusion: HS and KD are common in Chinese college students, and more attention and research is warranted.

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