PARP INHIBITORS IN OVARIAN CANCER: TOXICITY PROFILE

Abstract

Today, the role of the genetic factor in the etiology of ovarian cancer is unquestionable. Genetic disorders in low-differentiated serous adenocarcinoma of ovaries in about 50 per cent of cases occur in the form of a lack of homologous DNA reparation. About 2/3 of these cases are associated with mutations in BRCA genes. The use of PARP inhibitors is a promising direction in the treatment of BRCA-mutated ovarian cancer, and a number of studies have proven their advantage. But because they are used in supporting mode, one of the basic requirements for this group of drugs is the toxicity profile. The most common complications in taking PARP-inhibitors are nausea, fatigue, vomiting, anaemia, thrombocytopenia. Olaparib has the lowest toxicity range of all the PARP inhibitors known today in the treatment of ovarian cancer.

Keywords

• ovarian cancer
• parp inhibitors
• toxicity