从东西方种族差异看缺血性卒中抗血小板治疗策略选择 Strategy Selection of Antiplatelet Therapy for Ischemic Stroke in terms of the Ethnic Differences between Easterners and Westerners

Abstract

全球卒中的疾病负担沉重，抗血小板治疗是缺血性卒中二级预防的必要手段，然而东西 方人群的疾病特点存在差异，可能对抗血小板治疗的选择产生影响。本综述从卒中发病特点、患者复 发和出血风险差异以及抗血小板治疗反应多样性等多角度出发，探讨适合亚洲人群的缺血性卒中抗 血小板治疗方案。 Abstract: Stroke has become a global disease burden. Antiplatelet therapy is a necessary method for secondary prevention of ischemic stroke. However, there are differences between Easterners and Westerners on features of disease, which may lead to different antiplatelet therapy. Through the analysis of difference in disease characteristics, risk of recurrence and bleeding, and variability of platelet response, this review will explore the appropriate antiplatelet therapy for ischemic stroke patients in Asia.

Keywords

• 卒中
• 抗血小板药物
• 二级预防
• 基因多态性
• stroke
• antiplatelet drugs
• secondary prevention
• genetic polymorphism