Metabolomics and its Applications in Cancer Cachexia

Pengfei Cui; Xiaoyi Li; Caihua Huang; Qinxi Li; Donghai Lin

doi:10.3389/fmolb.2022.789889

Frontiers in Molecular Biosciences (Feb 2022)

Metabolomics and its Applications in Cancer Cachexia

Pengfei Cui,
Xiaoyi Li,
Caihua Huang,
Qinxi Li,
Donghai Lin

Affiliations

Pengfei Cui: College of Food and Pharmacy, Xuchang University, Xuchang, China
Xiaoyi Li: Xuchang Central Hospital, Xuchang, China
Caihua Huang: Department of Physical Education, Xiamen University of Technology, Xiamen, China
Qinxi Li: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China
Donghai Lin: Key Laboratory for Chemical Biology of Fujian Province, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China

DOI: https://doi.org/10.3389/fmolb.2022.789889
Journal volume & issue: Vol. 9

Abstract

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Cancer cachexia (CC) is a complicated metabolic derangement and muscle wasting syndrome, affecting 50–80% cancer patients. So far, molecular mechanisms underlying CC remain elusive. Metabolomics techniques have been used to study metabolic shifts including changes of metabolite concentrations and disturbed metabolic pathways in the progression of CC, and expand further fundamental understanding of muscle loss. In this article, we aim to review the research progress and applications of metabolomics on CC in the past decade, and provide a theoretical basis for the study of prediction, early diagnosis, and therapy of CC.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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