NEW MOLECULAR TECHNOLOGIES IN GENETIC DIAGNOSIS OF MALE INFERTILITY

Abstract

In recent years, the accelerated development of technologies in the field of molecular genetics and cytogenetics has led to significant opportunities of the research and diagnosis of mutations and variations of the genome. This article provides a brief review of new molecular technology, also as the results of their use in reproductive medicine and their perspectives in the genetic diagnosis of male infertility.

Keywords

• male infertility
• spermatogenesis
• azoospermia
• oligozoospermia
• disorders of sex development
• next-generation sequencing
• array comparative genomic hybridization
• copy number variation
• gene mutations
• single nucleotide polymorphism