Frontiers in Cell and Developmental Biology (Nov 2021)

Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases

  • Meng-Yi Luo,
  • Meng-Yi Luo,
  • Jian-Hui Su,
  • Jian-Hui Su,
  • Shao-Xin Gong,
  • Na Liang,
  • Wen-Qian Huang,
  • Wen-Qian Huang,
  • Wei Chen,
  • Wei Chen,
  • Ai-Ping Wang,
  • Ai-Ping Wang,
  • Ying Tian

DOI
https://doi.org/10.3389/fcell.2021.733908
Journal volume & issue
Vol. 9

Abstract

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The dynamic balance of cardiomyocytes and neurons is essential to maintain the normal physiological functions of heart and brain. If excessive cells die in tissues, serious Cardio-Cerebrovascular Diseases would occur, namely, hypertension, myocardial infarction, and ischemic stroke. The regulation of cell death plays a role in promoting or alleviating Cardio-Cerebrovascular Diseases. Ferroptosis is an iron-dependent new type of cell death that has been proved to occur in a variety of diseases. In our review, we focus on the critical role of ferroptosis and its regulatory mechanisms involved in Cardio-Cerebrovascular Diseases, and discuss the important function of ferroptosis-related inhibitors in order to propose potential implications for the prevention and treatment of Cardio-Cerebrovascular Diseases.

Keywords