Clinical Features and Outcomes of VAP Due to Multidrug-Resistant <i>Klebsiella</i> spp.: A Retrospective Study Comparing Monobacterial and Polybacterial Episodes

Abstract

VAP due to multidrug-resistant (MDR) bacteria is a frequent infection among patients in ICUs. Patient characteristics and mortality in mono- and polybacterial cases of VAP may differ. A single-centre, retrospective 3-year study was conducted in the four ICUs of a Lithuanian referral university hospital, aiming to compare both the clinical features and the 60-day ICU all-cause mortality of monobacterial and polybacterial MDR Klebsiella spp. VAP episodes. Of the 86 MDR Klebsiella spp. VAP episodes analyzed, 50 (58.1%) were polybacterial. The 60-day mortality was higher (p Klebsiella spp. (46.4 vs. 17.6%). The ICU mortality (44.0 vs. 22.5%) was also higher in the polybacterial episodes. The monobacterial MDR Klebsiella spp. VAP was associated (p p Klebsiella spp. VAP had distinct demographic and clinical characteristics compared to monobacterial, and was associated with poorer outcomes.

Keywords

• ventilator-associated pneumonia
• <i>Klebsiella</i>
• multidrug-resistance
• antibiotic treatment optimisation
• aspiration pneumonia
• hospital-acquired pneumonia