Cancer Medicine (Feb 2021)

Comparison of the prevalence and associated factors of hyperactive delirium in advanced cancer patients between inpatient palliative care and palliative home care

  • Jun Hamano,
  • Masanori Mori,
  • Taketoshi Ozawa,
  • Jun Sasaki,
  • Masanori Kawahara,
  • Asumi Nakamura,
  • Kotaro Hashimoto,
  • Kazuhiro Hisajima,
  • Tomoyuki Koga,
  • Keiji Goto,
  • Kazuhiko Fukumoto,
  • Yuri Morimoto,
  • Masahiro Goshima,
  • Go Sekimoto,
  • Mika Baba,
  • Kiyofumi Oya,
  • Ryo Matsunuma,
  • Yukari Azuma,
  • Kengo Imai,
  • Tatsuya Morita,
  • Takuya Shinjo

DOI
https://doi.org/10.1002/cam4.3661
Journal volume & issue
Vol. 10, no. 3
pp. 1166 – 1179

Abstract

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Abstract Background Hyperactive delirium is known to increase family distress and the burden on health care providers. We compared the prevalence and associated factors of agitated delirium in advanced cancer patients between inpatient palliative care and palliative home care on admission and at 3 days before death. Methods This was a post hoc exploratory analysis of two multicenter, prospective cohort studies of advanced cancer patients, which were performed at 23 palliative care units (PCUs) between Jan and Dec 2017, and on 45 palliative home care services between July and Dec 2017. Results In total, 2998 patients were enrolled and 2829 were analyzed in this study: 1883 patients in PCUs and 947 patients in palliative home care. The prevalence of agitated delirium between PCUs and palliative home care was 5.2% (95% CI: 4.2% ‐ 6.3%) vs. 1.4% (0.7% ‐ 2.3%) on admission (p < 0.001) and 7.6% (6.4% ‐ 8.9%) vs. 5.4% (4.0% ‐ 7.0%) 3 days before death (p < 0.001). However, multivariate logistic regression analysis revealed that the place of care was not significantly associated with the prevalence of agitated delirium at 3 days before death after adjusting for prognostic factors, physical risk factors, and symptoms. Conclusions There was no significant difference in the prevalence of agitated delirium at 3 days before death between inpatient palliative care and palliative home care after adjusting for the patient background, prognostic factors, symptoms, and treatment.

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